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Cellosaurus HuH-4 (CVCL_B373)

[Text version]
Cell line name HuH-4
Synonyms huH-4; HUH-4; huH 4; HuH4
Accession CVCL_B373
Resource Identification Initiative To cite this cell line use: HuH-4 (RRID:CVCL_B373)
Comments Population: Japanese.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu265_Phe270del (c.790_807del18); Zygosity=Unspecified (PubMed=8389256).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=6268479
Nam-Ho Huh, Tadashi Utakoji;
Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone.
Gann 72:178-179(1981)

DOI=10.1007/978-4-431-68349-0_4
Jennifer J. Alexander;
Human hepatoma cell lines.
(In book chapter) Neoplasms of the liver; Okuda, Kunio & Ishak, Kamal George (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Ih-Chang Hsu, Takayoshi Tokiwa, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Tsung-Tang Sun, Curtis Craig Harris;
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A
So Tsuboi, Seishi Nagamori, Masahiro Miyazaki, Koichiro Mihara, Ken-ichi Fukaya, Kiichiro Teruya, Tsunenori Kosaka, Takao Tsuji, Masayoshi Namba;
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
J. Med. Virol. 48:133-140(1996)

Cross-references
Encyclopedic resources Wikidata; Q54896846
Polymorphism and mutation databases Cosmic; 934551
Cosmic; 2668281
IARC_TP53; 2010
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number15