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Cellosaurus HuH-4 (CVCL_B373)

[Text version]
Cell line name HuH-4
Synonyms huH-4; HUH-4; huH 4; HuH4
Accession CVCL_B373
Resource Identification Initiative To cite this cell line use: HuH-4 (RRID:CVCL_B373)
Comments Population: Japanese.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu265_Phe270del (c.790_807del18); Zygosity=Unspecified (PubMed=8389256).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=6268479
Huh N.-H., Utakoji T.
Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone.
Gann 72:178-179(1981)

DOI=10.1007/978-4-431-68349-0_4
Alexander J.J.
Human hepatoma cell lines.
(In) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo (1987)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Hsu I.C., Tokiwa T., Bennett W., Metcalf R.A., Welsh J.A., Sun T., Harris C.C.
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A
Tsuboi S., Nagamori S., Miyazaki M., Mihara K., Fukaya K.-i., Teruya K., Kosaka T., Tsuji T., Namba M.
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
J. Med. Virol. 48:133-140(1996)

Cross-references
Encyclopedic resources Wikidata; Q54896846
Polymorphism and mutation databases Cosmic; 934551
Cosmic; 2668281
IARC_TP53; 2010
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number14