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Cellosaurus TK-1 [Human astrocytoma] (CVCL_B325)

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Cell line name TK-1 [Human astrocytoma]
Accession CVCL_B325
Resource Identification Initiative To cite this cell line use: TK-1 [Human astrocytoma] (RRID:CVCL_B325)
Comments Problematic cell line: Contaminated. Shown to be a U-251MG derivative. Originally thought to originate from a 22 year old female patient with a glioblastoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00348.
Population: Caucasian.
Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0128

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S82010,12
D13S31710,11
D16S53912
TH019.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9183640
Koji Tsuboi, Yoshihiko Yoshii, Tadao Nose;
Establishment of human glioblastoma cell line 'TK-1'.
Hum. Cell 9:125-128(1996)

Cross-references
Cell line collections (Providers) JCRB; JCRB0128
JCRB; NIHS0181 - Discontinued
Cell line databases/resources cancercelllines; CVCL_B325
Biological sample resources BioSample; SAMN03151978
Encyclopedic resources Wikidata; Q54972517
Polymorphism and mutation databases Cosmic; 687587
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number27