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Cellosaurus PC/JW (CVCL_B262)

[Text version]
Cell line name PC/JW
Synonyms PC-JW; PCJW; JW
Accession CVCL_B262
Resource Identification Initiative To cite this cell line use: PC/JW (RRID:CVCL_B262)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.74+1G>A; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=16418264).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ10 (PC/JW/FI)
Sex of cell Female
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=6746117; DOI=10.1002/ijc.2910340109
Christos Paraskeva, Brenda G. Buckle, Denise Sheer, Caroline B. Wigley;
The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients.
Int. J. Cancer 34:49-56(1984)

PubMed=2253215
Suzanne J. Baker, Antonette C. Preisinger, John Milburn Jessup, Christos Paraskeva, Sanford David Markowitz, James K.V. Willson, Stanley R. Hamilton, Bert Vogelstein;
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
Cancer Res. 50:7717-7722(1990)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Encyclopedic resources Wikidata; Q54938520
Gene expression databases GEO; GSM1374825
Polymorphism and mutation databases Cosmic; 876725
Cosmic; 948837
Cosmic; 1043823
Cosmic; 1312308
Cosmic; 2760079
Cosmic; 2800582
IARC_TP53; 21709
IARC_TP53; 21755
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number20