Cellosaurus logo
expasy logo

Cellosaurus SKOV3-TAX/CBP (CVCL_B0WE)

[Text][XML][JSON]
Cell line name SKOV3-TAX/CBP
Accession CVCL_B0WE
Resource Identification Initiative To cite this cell line use: SKOV3-TAX/CBP (RRID:CVCL_B0WE)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31355; Carboplatin (CBP; Paraplatin).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=34535163; DOI=10.1186/s13048-021-00873-2; PMCID=PMC8447655
Jing Zhang, Su-Hong Xie, Lei Zhou, Xiao-Yu Tang, Xiao-Lin Guan, Min-Jie Deng, Hui Zheng, Yan-Chun Wang, Ren-Quan Lu, Lin Guo;
Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin.
J. Ovarian Res. 14:122.1-122.14(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B0WE
Encyclopedic resources Wikidata; Q108821312
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6