Cellosaurus cell line RAO-4 (CVCL

Cellosaurus RAO-4 (CVCL_B0CM)

Cross-references
Cell line name	RAO-4
Accession	CVCL_B0CM
Resource Identification Initiative	To cite this cell line use: RAO-4 (RRID:CVCL_B0CM)
Comments	Characteristics: Tumorigenic. Generates human mammary epithelial carcinoma when injected into nude mice (PubMed=16395697). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gln61Leu). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367. Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_B0CJ (RAO-1)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Telomerase immortalized cell line
Publications	PubMed=16395697; DOI=10.1002/ijc.21739 Cheng J.-M., Ding M., Aribi A., Shah P., Rao K. Loss of RAB25 expression in breast cancer. Int. J. Cancer 118:2957-2964(2006) PubMed=16729884; DOI=10.1186/1475-2867-6-15; PMCID=PMC1524989 Rao K., Alper O., Opheim K.E., Bonnet G., Wolfe K., Bryant E.M., O'Hara Larivee S.M., Porter P.L., McDougall J.K. Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells. Cancer Cell Int. 6:15.1-15.11(2006) PubMed=29022488; DOI=10.1177/1010428317724283 Joshi P.S., Modur V., Cheng J.-M., Robinson K., Rao K. Characterization of immortalized human mammary epithelial cell line HMEC 2.6. Tumor Biol. 39:1010428317724283-1010428317724283(2017)
Encyclopedic resources	Wikidata; Q108821208
Entry history
Entry creation	23-Sep-2021
Last entry update	19-Dec-2024
Version number	6