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Cellosaurus A549 IFITM2/3-KO (CVCL_B0A6)

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Cell line name A549 IFITM2/3-KO
Synonyms C1-3
Accession CVCL_B0A6
Resource Identification Initiative To cite this cell line use: A549 IFITM2/3-KO (RRID:CVCL_B0A6)
Comments Population: Caucasian.
Characteristics: Has also reduced expression of IFITM1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5413; IFITM2.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5414; IFITM3.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=30643282; DOI=10.1038/s41589-018-0213-2; PMCID=PMC6466627
Jennifer S. Spence, Rui-Na He, Hans-Heinrich Hoffmann, Tandrila Das, Emmanuelle Thinon, Charles Moen Rice, Tao Peng, Kartik Chandran, Howard Chi Hang;
IFITM3 directly engages and shuttles incoming virus particles to lysosomes.
Nat. Chem. Biol. 15:259-268(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B0A6
Encyclopedic resources Wikidata; Q108819811
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6