Cell line name |
MeWo VIN 5 |
Synonyms |
MeWo VIN 5.0; MeWo VIN; MeWo-vindesine 5 |
Accession |
CVCL_AZ77 |
Resource Identification Initiative |
To cite this cell line use: MeWo VIN 5 (RRID:CVCL_AZ77) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_36373; Vindesine. Omics: Proteomics; 2DE. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
|
Disease |
Cutaneous melanoma (NCIt: C3510) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0445 (MeWo) |
Sex of cell |
Male |
Age at sampling |
78Y |
Category |
Cancer cell line |
Publications | PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W Pranav Sinha, Sandra Kohl, Jochen Fischer, Gero Hutter, Monika Kern, Eckart Kottgen, Manfred Dietel, Hermann Lage, Martina Schnolzer, Dirk Schadendorf; Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis. Electrophoresis 21:3048-3057(2000) PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V Claudia Grottke, Klaus Mantwill, Manfred Dietel, Dirk Schadendorf, Hermann Lage; Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs. Int. J. Cancer 88:535-546(2000) PubMed=21475863; DOI=10.3892/mmr_00000134 Pawel Surowiak, Marcin Drag, Verena Materna, Manfred Dietel, Hermann Lage; Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines. Mol. Med. Rep. 2:543-548(2009) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_AZ77
|
Encyclopedic resources |
Wikidata; Q54905346
|
Entry history |
Entry creation | 02-May-2016 |
Last entry update | 10-Apr-2025 |
Version number | 15 |
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