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Cellosaurus K562/CP (CVCL_AZ73)

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Cell line name K562/CP
Synonyms K-562/CP
Accession CVCL_AZ73
Resource Identification Initiative To cite this cell line use: K562/CP (RRID:CVCL_AZ73)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=25356864; DOI=10.1038/cddis.2014.461; PMCID=PMC4649536
Chun-Lai Nie, Y. Luo, Xin-Yu Zhao, Na Luo, Ai-Ping Tong, Xiao-Qing Liu, Zhu Yuan, C. Wang, Yu-Quan Wei;
Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.
Cell Death Dis. 5:e1495.1-e1495.13(2014)

Cross-references
Anatomy/cell type resources BTO; BTO_0005801
Encyclopedic resources Wikidata; Q54899407
Entry history
Entry creation02-May-2016
Last entry update19-Dec-2024
Version number16