Cellosaurus cell line AN4;11 (CVCL

Cross-references
Cell line name	AN4;11
Synonyms	AN4-11
Accession	CVCL_AY52
Resource Identification Initiative	To cite this cell line use: AN4;11 (RRID:CVCL_AY52)
Comments	Characteristics: Established from a tumor produced by injection of the leukemic cells into the peritoneum of SCID mice (PubMed=8353274).
Sequence variations	Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (PubMed=8358709).
Disease	Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	8M
Category	Cancer cell line
Publications	PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080 Chien-Shing Chen, Joanne M. Hilden, Joy Frestedt, Peter H. Domer, Roderick Moore, Stanley Joel Korsmeyer, John H. Kersey; The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. Blood 82:1080-1085(1993) PubMed=8358709 Joanne M. Hilden, Chien-Shing Chen, Roderick Moore, Joy Frestedt, John H. Kersey; Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia. Cancer Res. 53:3853-3856(1993)
Encyclopedic resources	Wikidata; Q54749899
Polymorphism and mutation databases	Cosmic; 2393013
Entry history
Entry creation	02-May-2016
Last entry update	19-Dec-2024
Version number	8