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Cellosaurus NCI-H226Br (CVCL_AX73)

[Text version]
Cell line name NCI-H226Br
Synonyms H226Br; H226br; 226Br
Accession CVCL_AX73
Resource Identification Initiative To cite this cell line use: NCI-H226Br (RRID:CVCL_AX73)
Comments Population: Caucasian.
Characteristics: Established from brain metastasis tumor of athymic BALB/c mice after carotid artery injection of parent cell line.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ile254Val (c.760A>G); ClinVar=VCV000406605; Zygosity=Homozygous (PubMed=8089864).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1544 (NCI-H226)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

PubMed=8089864; DOI=10.1093/jnci/86.19.1458
Fujiwara T., Cai D.W., Georges R.N., Mukhopadhyay T., Grimm E.A., Roth J.A.
Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model.
J. Natl. Cancer Inst. 86:1458-1462(1994)

PubMed=7634243; DOI=10.1016/0304-3835(95)03845-N
Hwang C.-C., Fang K., Li L., Shih S.H.
Insulin-like growth factor-I is an autocrine regulator for the brain metastatic variant of a human non-small cell lung cell line.
Cancer Lett. 94:157-163(1995)

Cai D.W., Mukhopadhyay T., Roth J.A.
Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA.
Cancer Gene Ther. 2:199-205(1995)

PubMed=8956792; DOI=10.1038/bjc.1996.629
Fang K.
An enhanced and sensitive autocrine stimulation by transforming growth factor-alpha is acquired in the brain metastatic variant of a human non-small-cell lung cancer cell line.
Br. J. Cancer 74:1776-1782(1996)

PubMed=9498829; DOI=10.1007/s004320050127
Perdomo J.A., Naomoto Y., Haisa M., Fujiwara T., Hamada M., Yasuoka Y., Tanaka N.
In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer.
J. Cancer Res. Clin. Oncol. 124:10-18(1998)

Cell line databases/resources cancercelllines; CVCL_AX73
Anatomy/cell type resources BTO; BTO:0000171
Encyclopedic resources Wikidata; Q54907949
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number11