Cell line name |
NCI-H226Br |
Synonyms |
H226Br; H226br; 226Br |
Accession |
CVCL_AX73 |
Resource Identification Initiative |
To cite this cell line use: NCI-H226Br (RRID:CVCL_AX73) |
Comments |
Population: Caucasian. Characteristics: Established from brain metastasis tumor of athymic BALB/c mice after carotid artery injection of parent cell line. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile254Val (c.760A>G); ClinVar=VCV000406605; Zygosity=Homozygous (PubMed=8089864).
|
Disease |
Pleural epithelioid mesothelioma (NCIt: C45662) Pleural mesothelioma (ORDO: Orphanet_50251) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_1544 (NCI-H226) |
Sex of cell |
Male |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=8089864; DOI=10.1093/jnci/86.19.1458 Toshiyoshi Fujiwara, De-Wei Cai, Renee N. Georges, Tapas Mukhopadhyay, Elizabeth A. Grimm, Jack Alan Roth; Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J. Natl. Cancer Inst. 86:1458-1462(1994) PubMed=7634243; DOI=10.1016/0304-3835(95)03845-N Chiu-Chin Hwang, Kang Fang, Li-Min Li, Stephen H. Shih; Insulin-like growth factor-I is an autocrine regulator for the brain metastatic variant of a human non-small cell lung cell line. Cancer Lett. 94:157-163(1995) PubMed=8528963 De-Wei Cai, Tapas Mukhopadhyay, Jack Alan Roth; Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA. Cancer Gene Ther. 2:199-205(1995) PubMed=8956792; DOI=10.1038/bjc.1996.629; PMCID=PMC2077222 Kang Fang; An enhanced and sensitive autocrine stimulation by transforming growth factor-alpha is acquired in the brain metastatic variant of a human non-small-cell lung cancer cell line. Br. J. Cancer 74:1776-1782(1996) PubMed=9498829; DOI=10.1007/s004320050127 Jose Antonio Perdomo, Yoshio Naomoto, Minoru Haisa, Toshiyoshi Fujiwara, Madoka Hamada, Yasuo Yasuoka, Noriaki Tanaka; In vivo influence of p53 status on proliferation and chemoradiosensitivity in non-small-cell lung cancer. J. Cancer Res. Clin. Oncol. 124:10-18(1998) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_AX73
|
Anatomy/cell type resources |
BTO; BTO_0000171
|
Encyclopedic resources |
Wikidata; Q54907949
|
Entry history |
Entry creation | 02-May-2016 |
Last entry update | 19-Dec-2024 |
Version number | 12 |
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