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Cellosaurus IRM2 (CVCL_AW96)

[Text version]
Cell line name IRM2
Synonyms IRM-2
Accession CVCL_AW96
Resource Identification Initiative To cite this cell line use: IRM2 (RRID:CVCL_AW96)
Comments Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108
Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585
Bhatt S., Matthews J., Parvin S., Sarosiek K.A., Zhao D.-K., Jiang X.-Y., Isik E., Letai A.G., Lossos I.S.
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AW96
Encyclopedic resources Wikidata; Q54898249
Gene expression databases GEO; GSM119540
GEO; GSM629488
GEO; GSM629489
Polymorphism and mutation databases Cosmic; 2297000
Progenetix; CVCL_AW96
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number9