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Cellosaurus IRM2 (CVCL_AW96)

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Cell line name IRM2
Synonyms IRM-2
Accession CVCL_AW96
Resource Identification Initiative To cite this cell line use: IRM2 (RRID:CVCL_AW96)
Comments Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731
Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A. Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L. Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J. Calasanz ...Show all 18 authors... , Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S. Lossos, Miguel Angel Piris, Martin E. Fernandez-Zapico, Jose Angel Martinez-Climent; Show fewer authors
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, De-Kuang Zhao, Xiao-Yu Jiang, Elif Isik, Anthony George Letai, Izidore S. Lossos;
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AW96
Encyclopedic resources Wikidata; Q54898249
Gene expression databases GEO; GSM119540
GEO; GSM629488
GEO; GSM629489
Polymorphism and mutation databases Cosmic; 2297000
Progenetix; CVCL_AW96
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number10