Cellosaurus cell line MUG-CC1 (CVCL

Cellosaurus MUG-CC1 (CVCL_AV05)

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Cell line name

MUG-CC1

Synonyms

Medical University of Graz-Clivus Chordoma 1

Accession

CVCL_AV05

Resource Identification Initiative

To cite this cell line use: MUG-CC1 (RRID:CVCL_AV05)

Comments

Doubling time: 109.16 +- 18.79 hours (PubMed=27072875); ~12 days (ATCC=CRL-3327); ~7 days (DSMZ=ACC-957); 15 days (Chordoma Foundation).
Omics: Transcriptomics; Microarray.
Omics: Variations; CNV analysis.
Derived from site: In situ; Bone, cranium, clivus; UBERON=UBERON_0004108.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).

HLA typing

Source: Chordoma Foundation

Class I
HLA-A	A*24

Disease

Clivus chordoma (NCIt: C5412)
Chordoma (ORDO: Orphanet_178)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_DE11 ! MUG-CC1-LCL

Sex of cell

Male

Age at sampling

72Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-957; PubMed=27072875

Markers:

Amelogenin	X
CSF1PO	11
D2S1338	17
D3S1358	16
D5S818	11,12
D7S820	8,11
D8S1179	13,15
D13S317	12 (DSMZ=ACC-957) 12,13 (PubMed=27072875)
D16S539	9,14 (PubMed=27072875) 14 (DSMZ=ACC-957)
D18S51	12
D19S433	15
D21S11	28
FGA	23
Penta D	13
Penta E	10
TH01	9.3
TPOX	8,11
vWA	16,18

Web pages

Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/mug-cc1/

Publications

PubMed=27072875; DOI=10.1038/srep24195; PMCID=PMC4829844
Verena Gellner, Peter Valentin Tomazic, Birgit Lohberger, Katharina Meditz, Ellen Heitzer, Michael Mokry, Wolfgang Koele, Andreas Leithner, Bernadette Liegl-Atzwanger, Beate Rinner;
Establishment of clival chordoma cell line MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies.
Sci. Rep. 6:24195.1-24195.9(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032.1-2032.12(2017)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3327
DSMZ; ACC-957

Cell line databases/resources

cancercelllines; CVCL_AV05

Encyclopedic resources

Wikidata; Q54907054

Gene expression databases

GEO; GSM2495970
GEO; GSM2495971
GEO; GSM2495972

Entry history

Entry creation

02-May-2016

Last entry update

10-Apr-2025

Version number