| Cell line name |
HCT 116 BRCA2(-/-) clone 42 |
|---|
| Synonyms |
HCT 116 BRCA2 -/- [42]; HCT 116 BRCA2-/- |
|---|
| Accession |
CVCL_AS10 |
|---|
| Resource Identification Initiative |
To cite this cell line use: HCT 116 BRCA2(-/-) clone 42 (RRID:CVCL_AS10) |
|---|
| Comments |
Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; 1101; BRCA2.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon carcinoma (NCIt: C4910) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
48Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ECACC
Markers:| Amelogenin | X,Y |
| CSF1PO | 7,10 |
| D3S1358 | 12,13 |
| D5S818 | 10,11 |
| D7S820 | 11,12 |
| D8S1179 | 12,14 |
| D13S317 | 10,13 |
| D16S539 | 11,13 |
| D18S51 | 16,17 |
| D21S11 | 29,30 |
| FGA | 18,23 |
| Penta D | 9,13 |
| Penta E | 13,14 |
| TH01 | 8,9 |
| TPOX | 8 |
| vWA | 17,21 |
Run an STR similarity search on this cell line |
|---|
| Publications | PubMed=25043256; DOI=10.1002/path.4404
Xu H., Xian J., Vire E., McKinney S., Wei V., Wong J., Tong R., Kouzarides T., Caldas C., Aparicio S.
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.
J. Pathol. 234:386-397(2014) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
CancerTools; 152628
ECACC; 16071901
Ximbio; 152628
|
|---|
| Cell line databases/resources |
cancercelllines; CVCL_AS10
|
|---|
| Encyclopedic resources |
Wikidata; Q54881923
|
|---|
| Entry history |
|---|
| Entry creation | 02-May-2016 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 15 |
|---|
