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Cellosaurus SK-N-RA (CVCL_AQ53)

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Cell line name SK-N-RA
Accession CVCL_AQ53
Resource Identification Initiative To cite this cell line use: SK-N-RA (RRID:CVCL_AQ53)
Comments Problematic cell line: Probably contaminated. The STR profile is identical to that of the SK-N-AS cell line. Originally thought to originate from a neuroblastoma but the sex and age of the patient has not been reported.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1700 (SK-N-AS)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,24
D3S135814
D5S81811,12
D7S82011,13
D8S117913,14
D13S3179
D16S53914
D18S5114,15
D19S43312,14
D21S1132.2,33.2
FGA20,22
TH019.3
TPOX11,12
vWA16,17

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Publications

DOI=10.1159/000407025
Lawrence Helson, Mukesh Verma, Christiane Helson;
Vitamin E and human neuroblastoma.
(In book chapter) Modulation and mediation of cancer by vitamins; Meyskens, Frank L. Jr. & Prasad, Kedar N. (eds.); pp.258-265; Karger; Basel; Switzerland (1983)

PubMed=11507071
Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles Joseph Gomer, Timothy J. Triche, Charles Patrick Reynolds;
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Ahsan S. Farooqi, Rebecca A. Dagg, L. Mi Rim Choi, Jerry W. Shay, Charles Patrick Reynolds, Loretta M.S. Lau;
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

Cross-references
Encyclopedic resources Wikidata; Q54954483
Polymorphism and mutation databases IARC_TP53; 23823
Entry history
Entry creation02-May-2016
Last entry update29-Jun-2023
Version number11