| Cell line name |
SK-MEL-28-VR |
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| Accession |
CVCL_AP99 |
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| Resource Identification Initiative |
To cite this cell line use: SK-MEL-28-VR (RRID:CVCL_AP99) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Cutaneous melanoma (NCIt: C3510) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0526 (SK-MEL-28) |
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| Sex of cell |
Male |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=26497853; DOI=10.18632/oncotarget.5755; PMCID=PMC4747351
Neel M. Fofaria, Dennie T. Frederick, Ryan Joseph Sullivan, Keith Thomas Flaherty, Sanjay K. Srivastava;
Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.
Oncotarget 6:40535-40556(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_AP99
|
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| Encyclopedic resources |
Wikidata; Q54954017
|
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| Entry history |
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| Entry creation | 02-May-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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