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Cellosaurus WM983B-BR (CVCL_AP81)

[Text version]
Cell line name WM983B-BR
Synonyms WM983B BR; WM983BBR; WM983B-R
Accession CVCL_AP81
Resource Identification Initiative To cite this cell line use: WM983B-BR (RRID:CVCL_AP81)
Comments Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_131882; SB-590885.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=21156289; Wistar).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Phe (c.832_833CC>TT); Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6809 (WM983B)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Web pages Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023; PMCID=PMC3026446
Jessie Villanueva, Adina Vultur, John T. Lee, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Angela K. Cipolla, Bradley Wubbenhorst, Xiao-Wei Xu, Phyllis A. Gimotty, Damien Kee, Ademi Elena Santiago-Walker, Richard Letrero, Kurt D'Andrea ...Show all 21 authors... , Anitha Pushparajan, James E. Hayden, Kimberly Brown Dahlman, Sylvie G. Laquerre, Grant A. McArthur, Jeffrey A. Sosman, Katherine L. Nathanson, Meenhard Herlyn; Show fewer authors
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

PubMed=23285177; DOI=10.1371/journal.pone.0052760; PMCID=PMC3532357
Adam B. Schayowitz, Greg P. Bertenshaw, Emiko Jeffries, Timothy Schatz, James Cotton, Jessie Villanueva, Meenhard Herlyn, Clemens Krepler, Adina Vultur, Wei Xu, Gordon H. Yu, Lynn Mara Schuchter, Douglas P. Clark; Show fewer authors ...Show all 13 authors...
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:e52760.1-e52760.8(2012)

Cross-references
Cell line collections (Providers) Rockland; WM983BBR-01-0001
Cell line databases/resources cancercelllines; CVCL_AP81
Encyclopedic resources Wikidata; Q54994347
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number17