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Cellosaurus WM983B-BR (CVCL_AP81)

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Cell line name WM983B-BR
Synonyms WM983B BR; WM983BBR; WM983B-R
Accession CVCL_AP81
Resource Identification Initiative To cite this cell line use: WM983B-BR (RRID:CVCL_AP81)
Comments Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_131882; SB-590885.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=21156289; Wistar).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Phe (c.832_833CC>TT); Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6809 (WM983B)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Web pages Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023; PMCID=PMC3026446
Jessie Villanueva, Adina Vultur, John T. Lee, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Angela K. Cipolla, Bradley Wubbenhorst, Xiao-Wei Xu, Phyllis A. Gimotty, Damien Kee, Ademi Elena Santiago-Walker ...Show all 21 authors... , Richard Letrero, Kurt D'Andrea, Anitha Pushparajan, James E. Hayden, Kimberly Brown Dahlman, Sylvie G. Laquerre, Grant A. McArthur, Jeffrey A. Sosman, Katherine L. Nathanson, Meenhard Herlyn; Show fewer authors
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

PubMed=23285177; DOI=10.1371/journal.pone.0052760; PMCID=PMC3532357
Adam B. Schayowitz, Greg P. Bertenshaw, Emiko Jeffries, Timothy Schatz, James Cotton, Jessie Villanueva, Meenhard Herlyn, Clemens Krepler, Adina Vultur, Wei Xu, Gordon H. Yu ...Show all 13 authors... , Lynn Mara Schuchter, Douglas P. Clark; Show fewer authors
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:e52760.1-e52760.8(2012)

Cross-references
Cell line collections (Providers) Rockland; WM983BBR-01-0001
Cell line databases/resources cancercelllines; CVCL_AP81
Encyclopedic resources Wikidata; Q54994347
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number17