Cellosaurus cell line HSC 536N (CVCL

Cellosaurus HSC 536N (CVCL_AK36)

Cross-references
Cell line name	HSC 536N
Synonyms	HSC-536N; HSC536N; HSC 536/N; HSC/536N; GM13021
Accession	CVCL_AK36
Resource Identification Initiative	To cite this cell line use: HSC 536N (RRID:CVCL_AK36)
Comments	Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; HGNC:3584; FANCC; Simple; p.Leu554Pro (c.1661T>C); ClinVar=VCV000012043; Zygosity=Unspecified (Coriell=GM13021).
Disease	Fanconi anemia, complementation group C (NCIt: C125704) Fanconi anemia (ORDO: Orphanet_84)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_G045 (HSC 536)
Sex of cell	Male
Age at sampling	5Y
Category	Transformed cell line
Publications	PubMed=8822951; DOI=10.1182/blood.V88.6.2298.bloodjournal8862298 Upendra K. Marathi, Sherie R. Howell, Richard A. Ashmun, Thomas P. Brent; The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells. Blood 88:2298-2305(1996) PubMed=11926188; DOI=10.1182/blood.V99.7.2627a Timothy R. Rutherford, Nyree E. Myatt, Frances M. Gibson, Alan A. Clarke; The Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing. Blood 99:2627-2628(2002)
Cell line collections (Providers)	Coriell; GM13021
Cell line databases/resources	CLO; CLO_0013991
Biological sample resources	BioSample; SAMN00802016
Encyclopedic resources	Wikidata; Q54896373
Entry history
Entry creation	02-May-2016
Last entry update	14-Aug-2025
Version number	15