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Cellosaurus B-LCL-CDG2 (CVCL_A9Y1)

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Cell line name B-LCL-CDG2
Synonyms CDG-LCL2; CDG-LCL II; LCL-2
Accession CVCL_A9Y1
Resource Identification Initiative To cite this cell line use: B-LCL-CDG2 (RRID:CVCL_A9Y1)
Comments Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: CLS=302013
Class I
HLA-AA*02:01:01,31:01:02
HLA-BB*40:01:02,44:02:01
HLA-CC*03:04:01,05:01:01
Class II
HLA-DPDPB1*04:02:01,06:01:01
HLA-DQDQA1*03:01:01,03:02:01
DQB1*03:02:01,03:03:02
HLA-DRDRB1*04:04:01,09:01:02
Disease Congenital disorder of glycosylation type Ia (NCIt: C126868)
PMM2-CDG (ORDO: Orphanet_79318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Children
Category Transformed cell line
STR profile Source(s): CLS=302013

Markers:
AmelogeninX
CSF1PO9,12
D3S135817
D5S81811,12
D7S8209,10
D8S117911,13
D13S31711,14
D16S53913,14
D18S5116,17
D21S1129,31.2
FGA22,24
Penta D9,12
Penta E7,10
TH016,9.3
TPOX8,9
vWA15,16

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Publications

PubMed=9719677; DOI=10.1093/glycob/8.10.963
Markus Bergmann, Hans-Jurgen Gross, Fawzy Abdelatty, Peter Moller, Jaak Jaeken, Reinhard Schwartz-Albiez;
Abnormal surface expression of sialoglycans on B lymphocyte cell lines from patients with carbohydrate deficient glycoprotein syndrome I A (CDGS I A).
Glycobiology 8:963-972(1998)

PubMed=34420056; DOI=10.1093/glycob/cwab087
Antonio Parrado, Gonzalo Rubio-Pedraza, Mercedes Serrano, Maria Eugenia De la Morena-Barrio, Salvador Ibanez-Mico, Natalia Ruiz-Lafuente, Reinhard Schwartz-Albiez, Ana Esteve-Sole, Laia Alsina, Javier Corral, Trinidad Hernandez-Caselles;
Dissecting the transcriptional program of phosphomannomutase 2-deficient cells: lymphoblastoide B cell lines as a valuable model for congenital disorders of glycosylation studies.
Glycobiology 32:84-100(2022)

Cross-references
Cell line collections (Providers) CLS; 302013
Encyclopedic resources Wikidata; Q102113579
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9