Cell line name |
CTSC#438 |
Synonyms |
CRC-SC#438 |
Accession |
CVCL_A9WV |
Resource Identification Initiative |
To cite this cell line use: CTSC#438 (RRID:CVCL_A9WV) |
Comments |
Group: Cancer stem cell line. From: Sant Andrea Hospital; Rome; Italy. Microsatellite instability: Instable (MSI-high) (PubMed=33128777). Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972. |
Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Leu443Ser (c.1328T>C); Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Arg182Ter (c.544C>T); ClinVar=VCV001187876; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; 11204; SOX9; Simple; p.Thr243Profs*10 (c.723delC); ClinVar=VCV000817191; Zygosity=Unspecified (PubMed=33128777).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Sex of cell |
Female |
Age at sampling |
85Y |
Category |
Cancer cell line |
STR profile |
Source(s): PubMed=33128777
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083 Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L. UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response. Oncotarget 7:44113-44128(2016) PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552 Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L. Short tandem repeat profiling for the authentication of cancer stem-like cells. Int. J. Cancer 148:1489-1498(2021) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_A9WV
|
Encyclopedic resources |
Wikidata; Q102113751
|
Entry history |
Entry creation | 29-Oct-2020 |
Last entry update | 05-Oct-2023 |
Version number | 8 |
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