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Cellosaurus CTSC#438 (CVCL_A9WV)

[Text version]
Cell line name CTSC#438
Synonyms CRC-SC#438
Accession CVCL_A9WV
Resource Identification Initiative To cite this cell line use: CTSC#438 (RRID:CVCL_A9WV)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Instable (MSI-high) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Leu443Ser (c.1328T>C); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6768; SMAD2; Simple; p.Arg182Ter (c.544C>T); ClinVar=VCV001187876; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11204; SOX9; Simple; p.Thr243Profs*10 (c.723delC); ClinVar=VCV000817191; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX
CSF1PO11
D5S81811,14
D7S8209,10
D13S3179,12
D16S5399,10
TH016,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WV
Encyclopedic resources Wikidata; Q102113751
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number8