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Cellosaurus CTSC#398 (CVCL_A9WQ)

[Text version]
Cell line name CTSC#398
Synonyms CRC-SC#398
Accession CVCL_A9WQ
Resource Identification Initiative To cite this cell line use: CTSC#398 (RRID:CVCL_A9WQ)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Met314Ile (c.942G>T); ClinVar=VCV000517186; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Glu991Ter (c.2971G>T); ClinVar=VCV000186494; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg524Lys (c.1571G>A); ClinVar=VCV000132954; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg361Cys (c.1081C>T); ClinVar=VCV000008543; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX
CSF1PO11
D5S81812
D7S8208,10
D13S3178,10
D16S5399,14
TH016
TPOX10,12
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WQ
Encyclopedic resources Wikidata; Q102113743
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number8