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Cellosaurus CTSC#393 (CVCL_A9WP)

[Text version]
Cell line name CTSC#393
Synonyms CRC-SC#393; CSC11
Accession CVCL_A9WP
Resource Identification Initiative To cite this cell line use: CTSC#393 (RRID:CVCL_A9WP)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Ala440Thr (c.1318G>A); ClinVar=VCV000418008; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Ala759Asnfs*2 (c.2273_2285delAAGCCCTAGAAGC); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Val325Ile (c.973G>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Glu110Lys (c.328G>A); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Gln277Ter (c.829C>T); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Val (c.2909A>T); Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX,Y
CSF1PO13
D5S81812
D7S82012
D13S3179,12
D16S5399
TH017,9
TPOX8,11
vWA18

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Publications

PubMed=26956206; DOI=10.5966/sctm.2015-0214
De Angelis M.L., Zeuner A., Policicchio E., Russo G., Bruselles A., Signore M., Vitale S., De Luca G., Pilozzi E., Boe A., Stassi G., Ricci-Vitiani L., Amoreo C.A., Pagliuca A., Francescangeli F., Tartaglia M., De Maria R., Baiocchi M.
Cancer stem cell-based models of colorectal cancer reveal molecular determinants of therapy resistance.
Stem Cells Transl. Med. 5:511-523(2016)

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WP
Encyclopedic resources Wikidata; Q102113741
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7