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Cellosaurus CTSC#389 (CVCL_A9WN)

[Text version]
Cell line name CTSC#389
Synonyms CRC-SC#389; CSC10
Accession CVCL_A9WN
Resource Identification Initiative To cite this cell line use: CTSC#389 (RRID:CVCL_A9WN)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Instable (MSI-high) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Ala626Val (c.1877C>T); ClinVar=VCV001698991; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln366Ter (c.1096C>T); ClinVar=VCV000405490; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg497His (c.1490G>A); ClinVar=VCV000959550; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11204; SOX9; Simple; p.Gly461Cys (c.1381G>T); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81812,13,15
D7S8208,11
D13S31714,15
D16S5399,14
TH019,9.3
TPOX10,12
vWA15,18,19

Run an STR similarity search on this cell line
Publications

PubMed=26956206; DOI=10.5966/sctm.2015-0214
De Angelis M.L., Zeuner A., Policicchio E., Russo G., Bruselles A., Signore M., Vitale S., De Luca G., Pilozzi E., Boe A., Stassi G., Ricci-Vitiani L., Amoreo C.A., Pagliuca A., Francescangeli F., Tartaglia M., De Maria R., Baiocchi M.
Cancer stem cell-based models of colorectal cancer reveal molecular determinants of therapy resistance.
Stem Cells Transl. Med. 5:511-523(2016)

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WN
Encyclopedic resources Wikidata; Q102113740
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number8