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Cellosaurus CTSC#85 (CVCL_A9WL)

[Text version]
Cell line name CTSC#85
Synonyms CRC-SC#85
Accession CVCL_A9WL
Resource Identification Initiative To cite this cell line use: CTSC#85 (RRID:CVCL_A9WL)
Comments Group: Cancer stem cell line.
From: Sant Andrea Hospital; Rome; Italy.
Microsatellite instability: Stable (MSS) (PubMed=33128777).
Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg283Ter (c.847C>T); ClinVar=VCV000184999; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 583; APC; Simple; p.Ser1415Argfs*4 (c.4245delT); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Val54Ala (c.161T>C); Zygosity=Unspecified (PubMed=33128777).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg361Cys (c.1081C>T); ClinVar=VCV000008543; Zygosity=Unspecified (PubMed=33128777).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=33128777

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8189,12
D7S82010
D13S3178,12
D16S53911,13
TH016,7
TPOX8
vWA14

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Publications

PubMed=27286453; DOI=10.18632/oncotarget.9859
Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M., Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget 7:44113-44128(2016)

PubMed=33128777; DOI=10.1002/ijc.33370
Visconti P., Parodi F., Parodi B., Casarino L., Romano P., Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E., Ricci-Vitiani L.
Short tandem repeat profiling for the authentication of cancer stem-like cells.
Int. J. Cancer 148:1489-1498(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9WL
Encyclopedic resources Wikidata; Q102113759
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7