| Cell line name |
CTSC#18 |
| Synonyms |
CRC-SC#18 |
| Accession |
CVCL_A9WJ |
| Resource Identification Initiative |
To cite this cell line use: CTSC#18 (RRID:CVCL_A9WJ) |
| Comments |
Group: Cancer stem cell line. From: Sant Andrea Hospital; Rome; Italy. Microsatellite instability: Instable (MSI-high) (PubMed=33128777). Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972. |
| Sequence variations |
- Mutation; HGNC; HGNC:172; ACVR1B; Simple; p.Trp501Ter (c.1503G>A); Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Ala199Val (c.596C>T); ClinVar=VCV000246301; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gly2250Asp (c.6749G>A); ClinVar=VCV001502413; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Lys647Glu (c.1939A>G); Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323Metfs*21 (c.968delA); ClinVar=VCV000653412; Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:11641; TCF7L2; Simple; p.Ser569Profs*33 (c.1700delC); Zygosity=Unspecified (PubMed=33128777).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp148Ter (c.441dupT); Zygosity=Unspecified (PubMed=33128777).
|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Sex of cell |
Female |
| Age at sampling |
66Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): PubMed=33128777
Markers: Run an STR similarity search on this cell line |
| Publications | PubMed=27286453; DOI=10.18632/oncotarget.9859; PMCID=PMC5190083 Michele Signore, Mariachiara Buccarelli, Emanuela Pilozzi, Gabriele De Luca, Marianna Cappellari, Maurizio Fanciulli, Frauke Goeman, Elisa Melucci, Mauro Biffoni, Lucia Ricci-Vitiani; UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response. Oncotarget 7:44113-44128(2016) PubMed=33128777; DOI=10.1002/ijc.33370; PMCID=PMC7894552 Paola Visconti, Federica Parodi, Barbara Parodi, Lucia Casarino, Paolo Romano, Mariachiara Buccarelli, Roberto Pallini, Quintino Giorgio D'Alessandris, Andrea Montori, Emanuela Pilozzi, Lucia Ricci-Vitiani; Short tandem repeat profiling for the authentication of cancer stem-like cells. Int. J. Cancer 148:1489-1498(2021) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_A9WJ
|
| Encyclopedic resources |
Wikidata; Q102113738
|
| Entry history |
| Entry creation | 29-Oct-2020 |
| Last entry update | 19-Dec-2024 |
| Version number | 9 |
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