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Cellosaurus GIST882IMR (CVCL_A9N2)

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Cell line name GIST882IMR
Accession CVCL_A9N2
Resource Identification Initiative To cite this cell line use: GIST882IMR (RRID:CVCL_A9N2)
Comments Characteristics: Has lost KIT protein expression (PubMed=30488756).
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Lys642Glu (c.1924A>G); ClinVar=VCV000013866; Zygosity=Homozygous (from parent cell line).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7044 (GIST882)
Category Cancer cell line
Publications

PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111
Yu-Qing Tu, Rui Zuo, Nan Ni, Grant Eilers, Duo-Lin Wu, Yu-Ting Pei, Zuo-Ming Nie, Ye-Qing Wu, Yue-Hong Wu, Wen-Bin Ou;
Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression.
Cell Cycle 17:2577-2592(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9N2
Encyclopedic resources Wikidata; Q102113884
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7