Cellosaurus cell line NORWAY1010 fibroblast hTERT (CVCL

Cellosaurus NORWAY1010 fibroblast hTERT (CVCL_A9F7)

Cross-references
Cell line name	NORWAY1010 fibroblast hTERT
Synonyms	L140R hTERT
Accession	CVCL_A9F7
Resource Identification Initiative	To cite this cell line use: NORWAY1010 fibroblast hTERT (RRID:CVCL_A9F7)
Comments	Population: Caucasian. Characteristics: Transduced with a lentiviral vector containing a LTR-loxP-hTERT-SV40p-hisD-PuroR-LTR construct. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P06988; Escherichia coli hisD. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:6636; LMNA; Simple; p.Leu140Arg (c.419T>G); ClinVar=VCV000014507; Zygosity=Heterozygous (PubMed=23847654).
Disease	Werner syndrome (NCIt: C3447) Atypical Werner syndrome (ORDO: Orphanet_79474)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A9F6 (NORWAY1010 fibroblast)
Sex of cell	Male
Age at sampling	34Y
Category	Finite cell line
Publications	PubMed=23847654; DOI=10.3389/fgene.2013.00129; PMCID=PMC3701863 Bidisha Saha, Galynn Zitnik, Simon Johnson, Quyen Nguyen, Rosa Ana Risques, George M. Martin, Junko Oshima; DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations. Front. Genet. 4:129.1-129.12(2013)
Encyclopedic resources	Wikidata; Q102114657
Entry history
Entry creation	29-Oct-2020
Last entry update	14-Aug-2025
Version number	9