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Cellosaurus H460/CIS (CVCL_A9CH)

[Text version]
Cell line name H460/CIS
Accession CVCL_A9CH
Resource Identification Initiative To cite this cell line use: H460/CIS (RRID:CVCL_A9CH)
Comments Population: Caucasian.
Doubling time: 1.9 days (PubMed=11551417).
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line

PubMed=11551417; DOI=10.1016/s0169-5002(01)00205-7
Yoon S.-S., Ahn K.-S., Kim S.-H., Shim Y.M., Kim J.
In vitro establishment of cis-diammine-dichloroplatinum(II) resistant lung cancer cell line and modulation of apoptotic gene expression as a mechanism of resistant phenotype.
Lung Cancer 33:221-228(2001)

Cell line databases/resources cancercelllines; CVCL_A9CH
Encyclopedic resources Wikidata; Q108820357
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number5