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Cellosaurus BCK4 (CVCL_A9A5)

[Text version]
Cell line name BCK4
Synonyms BCK-4
Accession CVCL_A9A5
Resource Identification Initiative To cite this cell line use: BCK4 (RRID:CVCL_A9A5)
Comments Characteristics: ER-positive, PR-positive and ERBB2-negative. Has mucinous features. Established from a mouse xenograft.
Doubling time: ~120 hours (PubMed=23247610).
Omics: Transcriptomics; Microarray.
Miscellaneous: STR profile from personal communication of Atkinson, Jennifer M.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Invasive breast lobular carcinoma (NCIt: C7950)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11
D3S135814,15
D5S81811,12
D7S8209,11
D8S117912,16
D13S31712,13
D16S53913
D18S5113,14
D21S1130,30.2
FGA21,24
Penta D10,13
Penta E7,13
TH017,9.3
TPOX8,11
vWA16

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Publications

PubMed=23247610; DOI=10.1007/s10549-012-2377-x; PMCID=PMC3543987
Purevsuren Jambal, Melanie M. Badtke, J. Chuck Harrell, Virginia F. Borges, Miriam Denise Post, Grace Elizabeth Sollender, Monique A. Spillman, Kathryn Bloch Horwitz, Britta M. Jacobsen;
Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features.
Breast Cancer Res. Treat. 137:431-448(2013)

PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436
Matthias Christgen, Patrick W.B. Derksen;
Lobular breast cancer: molecular basis, mouse and cellular models.
Breast Cancer Res. 17:16.1-16.9(2015)

PubMed=27565181; DOI=10.1158/1541-7786.MCR-16-0167; PMCID=PMC5107172
Nicholas C. D'Amato, Michael A. Gordon, Beatrice Babbs, Nicole S. Spoelstra, Kiel T. Carson Butterfield, Kathleen C. Torkko, Vernon T. Phan, Valerie N. Barton, Thomas J. Rogers, Carol A. Sartorius, Anthony David Elias ...Show all 14 authors... , Jason Gertz, Britta M. Jacobsen, Jennifer K. Richer; Show fewer authors
Cooperative dynamics of AR and ER activity in breast cancer.
Mol. Cancer Res. 14:1054-1067(2016)

PubMed=29176653; DOI=10.1038/s41389-017-0002-x; PMCID=PMC5868054
J. Chuck Harrell, Thomas M. Shroka, Britta M. Jacobsen;
Estrogen induces c-Kit and an aggressive phenotype in a model of invasive lobular breast cancer.
Oncogenesis 6:396.1-396.16(2017)

PubMed=30228172; DOI=10.1158/0008-5472.CAN-18-1416; PMCID=PMC6507416
Nilgun Tasdemir, Emily Ann Bossart, Zhe-Qi Li, Li Zhu, Matthew J. Sikora, Kevin M. Levine, Britta M. Jacobsen, George Chien-Cheng Tseng, Nancy E. Davidson, Steffi Oesterreich;
Comprehensive phenotypic characterization of human invasive lobular carcinoma cell lines in 2D and 3D cultures.
Cancer Res. 78:6209-6222(2018)

PubMed=30317423; DOI=10.1007/s10549-018-4989-2; PMCID=PMC6813790
Anna Astashchanka, Thomas M. Shroka, Britta M. Jacobsen;
Mucin 2 (MUC2) modulates the aggressiveness of breast cancer.
Breast Cancer Res. Treat. 173:289-299(2019)

Cross-references
Encyclopedic resources Wikidata; Q102113608
Gene expression databases GEO; GSE101742
Entry history
Entry creation29-Oct-2020
Last entry update10-Apr-2025
Version number8