Cellosaurus cell line F16574 (CVCL

Cellosaurus F16574 (CVCL_A8YY)

[Text version]

Cell line name

F16574

Accession

CVCL_A8YY

Resource Identification Initiative

To cite this cell line use: F16574 (RRID:CVCL_A8YY)

Comments

Population: Caucasian.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.

Sequence variations

Mutation; HGNC; HGNC:620; APP; Simple; p.Val717Ile (c.2149G>A); ClinVar=VCV000018088; Zygosity=Heterozygous (PubMed=30045758).

Disease

Alzheimer's disease 1 (NCIt: C146894)
Early-onset autosomal dominant Alzheimer disease (ORDO: Orphanet_1020)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_A8YZ (UOMELBi002-A)

Sex of cell

Sex unspecified

Age at sampling

Age unspecified

Category

Induced pluripotent stem cell

Publications

PubMed=30045758; DOI=10.1186/s13195-018-0400-0; PMCID=PMC6060509
Celeste M. Karch, Damian Hernandez, Jen-Chyong Wang, Jacob Marsh, Alex W. Hewitt, Simon Hsu, Joanne Norton, Denise Levitch, Tamara Donahue, Wendy Sigurdson, Bernardino Ghetti ...Show all 19 authors... , Martin Farlow, Jasmeer Chhatwal, Sarah Berman, Carlos Cruchaga, John C. Morris, Randall John Bateman, Alice Pebay, Alison M. Goate; Show fewer authors
Dominantly Inherited Alzheimer Network (DIAN)
Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network.
Alzheimers Res. Ther. 10:69.1-69.11(2018)

PubMed=34088002; DOI=10.1016/j.scr.2021.102373; PMCID=PMC10084742
Damian Hernandez, Stephanie Morgan Schlicht, Maciej S. Daniszewski, Celeste M. Karch, Alison M. Goate, Alice Pebay;
Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I).
Stem Cell Res. 53:102373-102373(2021)

Cross-references

Encyclopedic resources

Wikidata; Q108820213

Entry history

Entry creation

23-Sep-2021

Last entry update

10-Apr-2025

Version number