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Cellosaurus JR1Nmyc9 (CVCL_A8SK)

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Cell line name JR1Nmyc9
Accession CVCL_A8SK
Resource Identification Initiative To cite this cell line use: JR1Nmyc9 (RRID:CVCL_A8SK)
Comments Characteristics: Expresses MYCN under the control of the CMV promoter (PubMed=10933967).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7559; MYCN.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Disease Embryonal rhabdomyosarcoma (NCIt: C8971)
Embryonal rhabdomyosarcoma (ORDO: Orphanet_99757)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J063 (JR-1)
Sex of cell Female
Age at sampling 7Y
Category Cancer cell line
Publications

PubMed=10933967; DOI=10.1006/mthe.2000.0064
Cynthia A. Pawlik, Rekha V. Iyengar, Erik J. Krull, Stephen E. Mason, Ruchi Khanna, Linda C. Harris, Philip M. Potter, Mary K. Danks, Sylvie M. Guichard;
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Mol. Ther. 1:457-463(2000)

Cross-references
Encyclopedic resources Wikidata; Q108820565
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number7