Cellosaurus cell line MDS-LGF (CVCL

Cellosaurus MDS-LGF (CVCL_A8QZ)

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Cell line name

MDS-LGF

Accession

CVCL_A8QZ

Resource Identification Initiative

To cite this cell line use: MDS-LGF (RRID:CVCL_A8QZ)

Comments

Population: Japanese.
Characteristics: IL3 independent. Has lost the H3C3 p.Lys28Met mutation of the parent cell line.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; HGNC:1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=29955132).

Disease

Myelodysplastic syndrome (NCIt: C3247)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_A8QV (MDS-L)

Sex of cell

Male

Age at sampling

52Y

Category

Cancer cell line

STR profile

Source(s): PubMed=29955132

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	15
D5S818	13
D7S820	11
D8S1179	11,13
D13S317	8
D16S539	9,10
D18S51	12,17
D21S11	30,32.2
FGA	23
Penta D	9
Penta E	16,18
TH01	6
TPOX	8,11
vWA	15,17

Publications

PubMed=29955132; DOI=10.1038/s41375-018-0189-7
Jun-ichiro Kida, Takayuki Tsujioka, Shin-ichiro Suemori, Shuichiro Okamoto, Kanae Sakakibara, Takayuki Takahata, Takahiro Yamauchi, Akira Kitanaka, Yumi Tohyama, Kaoru Tohyama;
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS.
Leukemia 32:1846-1850(2018)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A8QZ

Encyclopedic resources

Wikidata; Q108820891

Entry history

Entry creation

23-Sep-2021

Last entry update

10-Apr-2025

Version number