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Cellosaurus MDS-L/GFP-N (CVCL_A8QW)

[Text version]
Cell line name MDS-L/GFP-N
Accession CVCL_A8QW
Resource Identification Initiative To cite this cell line use: MDS-L/GFP-N (RRID:CVCL_A8QW)
Comments Population: Japanese.
Characteristics: Transduced with a 5'LTR-CMV-rsGFP-Neo-3'LTR construct.
Genetic integration: Method=Transduction; Gene=FPbase; JYYJ1; rsEGFP (Note=rsGFP, red-shifted GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Myelodysplastic syndrome (NCIt: C3247)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A8QV (MDS-L)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=11108571; DOI=10.1080/13684730050515787
Satoki Nakamura, Kazunori Ohnishi, Hitoshi Yoshida, Kaori Shinjo, Akihiro Takeshita, Kaoru Tohyama, Ryuzo Ohno, Yukio Koide;
Retrovirus-mediated gene transfer of granulocyte colony-stimulating factor receptor (G-CSFR) cDNA into MDS cells and induction of their differentiation by G-CSF.
Cytokines Cell. Mol. Ther. 6:61-70(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A8QW
Encyclopedic resources Wikidata; Q108820888
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number8