Cellosaurus cell line MCF-7 TTE-MBD2 (CVCL

Cellosaurus MCF-7 TTE-MBD2 (CVCL_A8P5)

Cross-references
Cell line name	MCF-7 TTE-MBD2
Accession	CVCL_A8P5
Resource Identification Initiative	To cite this cell line use: MCF-7 TTE-MBD2 (RRID:CVCL_A8P5)
Comments	Population: Caucasian. Characteristics: The transfected human MBD2 gene is N-terminally tagged with a Ty1-Ty1-ER (TTE) epitope tag. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6917; MBD2. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Omics: Genomics; ChIP-seq; MBD2. Omics: Genomics; ChIP-seq; Pol2. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=24927503; DOI=10.1371/journal.pone.0099603; PMCID=PMC4057170 Roberta Menafra, Arie B. Brinkman, Filomena Matarese, Gianluigi Franci, Stefanie J.J. Bartels, Luan Nguyen, Takashi Shimbo, Paul A. Wade, Nina C. Hubner, Hendrik Gerard Stunnenberg; Genome-wide binding of MBD2 reveals strong preference for highly methylated loci. PLoS ONE 9:e99603.1-e99603.12(2014)
Cell line databases/resources	cancercelllines; CVCL_A8P5
Encyclopedic resources	Wikidata; Q102114501
Gene expression databases	GEO; GSM1322266 GEO; GSM1322268 GEO; GSM1322269 GEO; GSM1388122 GEO; GSM1388124 GEO; GSM1388125 GEO; GSM1388126 GEO; GSM1388127
Entry history
Entry creation	29-Oct-2020
Last entry update	14-Aug-2025
Version number	11