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Cellosaurus CLC12N2 (CVCL_A8GH)

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Cell line name CLC12N2
Accession CVCL_A8GH
Resource Identification Initiative To cite this cell line use: CLC12N2 (RRID:CVCL_A8GH)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16412; NLRC4 (Note=With p.Leu152_Ala1024del, CARD domain, C12N2 construct).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5331; NOD2 (Note=With p.Met1_Ala216del, NACHT+LRR domains, C12N2 construct).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0218 (COLO 205)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): TKG=TKG 0802

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,13
D7S8209,10
D13S31710,12
D16S53912,13
TH018,9
TPOX11
vWA15

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Publications

PubMed=20500518; DOI=10.1111/j.1349-7006.2010.01610.x; PMCID=PMC11159384
Kou Motani, Kouji Kawase, Ryu Imamura, Takeshi Kinoshita, Hiroko Kushiyama, Takashi Suda;
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.
Cancer Sci. 101:1822-1827(2010)

Cross-references
Cell line collections (Providers) TKG; TKG 0802
Cell line databases/resources cancercelllines; CVCL_A8GH
Encyclopedic resources Wikidata; Q107114691
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number9