Cellosaurus cell line THP1-KO-NLRP3 (CVCL

Cross-references
Cell line name	THP1-KO-NLRP3
Accession	CVCL_A8AS
Resource Identification Initiative	To cite this cell line use: THP1-KO-NLRP3 (RRID:CVCL_A8AS)
Comments	Population: Japanese. Knockout cell: Method=Not specified; HGNC; HGNC:16400; NLRP3. Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line). Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease	Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A8AK (THP1-Null2)
Sex of cell	Male
Age at sampling	1Y
Category	Cancer cell line
Cell line collections (Providers)	InvivoGen; thp-konlrp3z
Cell line databases/resources	cancercelllines; CVCL_A8AS
Encyclopedic resources	Wikidata; Q107117088
Entry history
Entry creation	20-May-2021
Last entry update	10-Apr-2025
Version number	8