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Cellosaurus CHB-11 (CVCL_A822)

[Text version]
Cell line name CHB-11
Synonyms CHB11; BCHe005-A
Accession CVCL_A822
Resource Identification Initiative To cite this cell line use: CHB-11 (RRID:CVCL_A822)
Comments From: Children's Hospital Boston; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0010.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell

PubMed=18223642; DOI=10.1038/nbt1378
Lerou P.H., Yabuuchi A., Huo H.-G., Takeuchi A., Shea J., Cimini T., Ince T.A., Ginsburg E., Racowsky C., Daley G.Q.
Human embryonic stem cell derivation from poor-quality embryos.
Nat. Biotechnol. 26:212-214(2008)

PubMed=28445466; DOI=10.1038/nature22312
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Nature 545:229-233(2017)

Cell line databases/resources hPSCreg; BCHe005-A
ISCR; 76
NIHhESC; NIHhESC-10-0010
SKIP; SKIP001988
Encyclopedic resources Wikidata; Q54811743
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number17