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Cellosaurus 2XSB (CVCL_A7NI)

[Text version]
Cell line name 2XSB
Accession CVCL_A7NI
Resource Identification Initiative To cite this cell line use: 2XSB (RRID:CVCL_A7NI)
Comments Population: Caucasian.
Doubling time: 28.0 +- 3.09 hours (Note=At 6th passage), 27.3 +- 4.06 hours (Note=At 54th passage) (PubMed=33707600).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Misspelling: X2SB; Note=In Cellosaurus release 38.
Derived from site: In situ; Right brachial nerve; UBERON=UBERON_0001814.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:19291; CSMD3; Simple; p.Trp3337Ter (c.10010G>A); Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:2976; DNMT1; Simple; c.2586+1G>A; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=33707600).
  • Mutation; HGNC; HGNC:6697; LRP5; Simple; p.Arg428Ter (c.1282C>T); ClinVar=VCV000006269; Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:7765; NF1; None_reported; -; Zygosity=- (PubMed=33707600).
  • Mutation; HGNC; HGNC:8059; NUMA1; Simple; p.Leu1167Alafs*39 (c.3499_3500delCT); Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro38Ser (c.112C>T); ClinVar=VCV000127688; Zygosity=Homozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His178Asp (c.532C>G); ClinVar=VCV000482223; Zygosity=Homozygous (PubMed=33707600).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=33707600

Markers:
AmelogeninX
CSF1PO15
D2S133817,26
D3S135816
D5S81811
D7S8208,9
D8S117911,13
D13S3178
D16S53911
D18S5115
D19S43314,15.2
D21S1130,30.2
FGA19,23
TH017,9.3
TPOX11,12
vWA17,18

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Publications

PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412
Longo J.F., Brosius S.N., Znoyko I., Alers V.A., Jenkins D.P., Wilson R.C., Carroll A.J. 3rd, Wolff D.J., Roth K.A., Carroll S.L.
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Sci. Rep. 11:5690.1-5690.19(2021)

Cross-references
Cell line collections (Providers) ABM; T8335
CancerTools; 161801
Cell line databases/resources cancercelllines; CVCL_A7NI
Encyclopedic resources Wikidata; Q107117558
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number7