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Cellosaurus 2XSB (CVCL_A7NI)

[Text version]
Cell line name 2XSB
Accession CVCL_A7NI
Resource Identification Initiative To cite this cell line use: 2XSB (RRID:CVCL_A7NI)
Comments Population: Caucasian.
Doubling time: 28.0 +- 3.09 hours (Note=At 6th passage), 27.3 +- 4.06 hours (Note=At 54th passage) (PubMed=33707600).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Misspelling: X2SB; Note=In Cellosaurus release 38.
Derived from site: In situ; Right brachial nerve; UBERON=UBERON_0001814.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:19291; CSMD3; Simple; p.Trp3337Ter (c.10010G>A); Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:2976; DNMT1; Simple; c.2586+1G>A; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=33707600).
  • Mutation; HGNC; HGNC:6697; LRP5; Simple; p.Arg428Ter (c.1282C>T); ClinVar=VCV000006269; Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:7765; NF1; None_reported; -; Zygosity=- (PubMed=33707600).
  • Mutation; HGNC; HGNC:8059; NUMA1; Simple; p.Leu1167Alafs*39 (c.3499_3500delCT); Zygosity=Heterozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro38Ser (c.112C>T); ClinVar=VCV000127688; Zygosity=Homozygous (PubMed=33707600).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His178Asp (c.532C>G); ClinVar=VCV000482223; Zygosity=Homozygous (PubMed=33707600).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): PubMed=33707600

Markers:
AmelogeninX
CSF1PO15
D2S133817,26
D3S135816
D5S81811
D7S8208,9
D8S117911,13
D13S3178
D16S53911
D18S5115
D19S43314,15.2
D21S1130,30.2
FGA19,23
TH017,9.3
TPOX11,12
vWA17,18

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Publications

PubMed=33707600; DOI=10.1038/s41598-021-85055-2; PMCID=PMC7952412
Jody Fromm Longo, Stephanie N. Brosius, Iya Znoyko, Victoria A. Alers, Dorea Pleasant Jenkins, Robert C. Wilson, Andrew J. Carroll 3rd, Daynna J. Wolff, Kevin A. Roth, Steven Lewis Carroll;
Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line.
Sci. Rep. 11:5690.1-5690.19(2021)

Cross-references
Cell line collections (Providers) ABM; T8335
CancerTools; 161801
Cell line databases/resources cancercelllines; CVCL_A7NI
Encyclopedic resources Wikidata; Q107117558
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number7