Cellosaurus cell line UKAi002-B-1 (CVCL

Cellosaurus UKAi002-B-1 (CVCL_A7GX)

[Text version]

Cell line name

UKAi002-B-1

Synonyms

PV1 JAK2 V617F het:CXCL4 KO; JAK2 V617Fhet:CXCL4KO

Accession

CVCL_A7GX

Resource Identification Initiative

To cite this cell line use: UKAi002-B-1 (RRID:CVCL_A7GX)

Comments

From: Universitatsklinikum Aachen; Aachen; Germany.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:8861; PF4.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Heterozygous (PubMed=34391098).

Disease

Polycythemia vera (NCIt: C3336)
Polycythemia vera (ORDO: Orphanet_729)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_A7GV (UKAi002-B)

Sex of cell

Female

Age at sampling

45Y

Category

Induced pluripotent stem cell

STR profile

Source(s): PubMed=34391098

Markers:

Amelogenin	X
CSF1PO	12
D2S1338	17,25
D3S1358	15,16
D5S818	11,13
D7S820	8,9
D8S1179	12,15
D13S317	12,13
D16S539	11,14
D18S51	16
D19S433	13,14
D21S11	29,30.2
FGA	24
TH01	9,9.3
TPOX	8,10
vWA	15,16

Publications

PubMed=34391098; DOI=10.1016/j.scr.2021.102490
Janik Boehnke, Salim Atakhanov, Marcelo Augusto Szymanski de Toledo, Herdit M. Schuler, Stephanie Sontag, Nicolas Chatain, Steffen Koschmieder, Tim Henrik Brummendorf, Rafael Kramann, Martin Zenke;
CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation.
Stem Cell Res. 55:102490-102490(2021)

Cross-references

Cell line databases/resources

hPSCreg; UKAi002-B-1

Biological sample resources

BioSamples; SAMEA8686795

Encyclopedic resources

Wikidata; Q107117215

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number