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Cellosaurus XG-6 (CVCL_A771)

[Text version]
Cell line name XG-6
Synonyms XG6; XG 6
Accession CVCL_A771
Resource Identification Initiative To cite this cell line use: XG-6 (RRID:CVCL_A771)
Comments Characteristics: Produces IgG lambda.
Characteristics: IL6 dependent.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck, Catherine.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
HLA typing Source: Direct_author_submission
Class I
HLA-AA*02
HLA-BB*15,37
HLA-CC*03:03,06:02
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=8204890; DOI=10.1182/blood.V83.12.3654.3654
Xue-Guang Zhang, Jean-Philippe Gaillard, Nelly Robillard, Zhao-Yang Lu, Zong-Jiang Gu, Michel Jourdan, Jean-Michel Boiron, Francois-Regis Bataille, Bernard Klein;
Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma.
Blood 83:3654-3663(1994)

PubMed=10557056; DOI=10.1038/sj.leu.2401563
S. Yoshida, Naozo Nakazawa, S. Iida, Yoshihito Hayami, S. Sato, Atsushi Wakita, S. Shimizu, Masafumi Taniwaki, R. Ueda;
Detection of MUM1/IRF4-IgH fusion in multiple myeloma.
Leukemia 13:1812-1816(1999)

PubMed=10583232; DOI=10.1046/j.1365-2141.1999.01705.x
Denis Puthier, Sophie Derenne, Sophie Barille, Philippe Moreau, Jean-Luc Harousseau, Francois-Regis Bataille, Martine Amiot;
Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.
Br. J. Haematol. 107:392-395(1999)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16956823
Francois-Regis Bataille, Gaatan Jego, Nelly Robillard, Sophie Barille-Nion, Jean-Luc Harousseau, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck;
The phenotype of normal, reactive and malignant plasma cells Identification of 'many and multiple myelomas' and of new targets for myeloma therapy.
Haematologica 91:1234-1240(2006)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Jonathan J. Keats, Rafael Fonseca, Marta Chesi, Roelandt Schop, Angela Baker, Wee-Joo Chng, Scott Van Wier, Rodger Tiedemann, Chang-Xin Shi, Michael Sebag, Esteban Braggio ...Show all 30 authors... , Travis Henry, Yuan-Xiao Zhu, Homer Fogle, Tammy L. Price-Troska, Gregory J. Ahmann, Catherine Mancini, Leslie A. Brents, Shaji K. Kumar, Philip Robert Greipp, Angela Dispenzieri, Barb Bryant, George Mulligan, Laurakay Bruhn, Michael T. Barrett, Riccardo Valdez, Jeffrey M. Trent, A. Keith Stewart, John D. Carpten, Peter Leif Bergsagel; Show fewer authors
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235
Jerome Moreaux, Bernard Klein, Francois-Regis Bataille, Geraldine Descamps, Sophie Maiga, Dirk Hose, Hartmut Goldschmidt, Anna Jauch, Thierry Reme, Michel Jourdan, Martine Amiot, Catherine Pellat-Deceunynck;
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660
Benoit Tessoulin, Agnes Moreau-Aubry, Geraldine Descamps, Patricia Gomez-Bougie, Sophie Maiga, Alban Gaignard, David Chiron, Emmanuelle Menoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck;
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line databases/resources Lonza; 94
Encyclopedic resources Wikidata; Q54994714
Gene expression databases ArrayExpress; E-TABM-1088
Polymorphism and mutation databases Cosmic; 2081413
Cosmic; 2367259
Cosmic; 2809772
IARC_TP53; 28492
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number24