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Cellosaurus ARK (CVCL_A760)

[Text version]
Cell line name ARK
Synonyms Ark; ark; ARK-B
Accession CVCL_A760
Resource Identification Initiative To cite this cell line use: ARK (RRID:CVCL_A760)
Comments Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=11157491).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=8427968; DOI=10.1182/blood.V81.3.767.767
Ridley R.C., Xiao H.-Q., Hata H., Woodliff J., Epstein J., Sanderson R.D.
Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen.
Blood 81:767-774(1993)

PubMed=8051085; DOI=10.1016/S0021-9258(17)32120-8
Liebersbach B.F., Sanderson R.D.
Expression of syndecan-1 inhibits cell invasion into type I collagen.
J. Biol. Chem. 269:20013-20019(1994)

PubMed=8943038; DOI=10.1073/pnas.93.24.13931
Bergsagel P.L., Chesi M., Nardini E., Brents L.A., Kirby S.L., Kuehl W.M.
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=11001907; DOI=10.1182/blood.V96.7.2528
Borset M., Hjertner O., Yaccoby S., Epstein J., Sanderson R.D.
Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparin-binding proteins.
Blood 96:2528-2536(2000)

PubMed=11157491; DOI=10.1182/blood.V97.3.729
Chesi M., Brents L.A., Ely S.A., Bais C., Robbiani D.F., Mesri E.A., Kuehl W.M., Bergsagel P.L.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=11167840; DOI=10.1046/j.1365-2141.2001.02531.x
Chiriva-Internati M., Du J.-H., Cannon M., Barlogie B., Yi Q.
Myeloma-reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway.
Br. J. Haematol. 112:410-420(2001)

PubMed=14555701
Shammas M.A., Shmookler Reis R.J., Akiyama M., Koley H., Chauhan D., Hideshima T., Goyal R.K., Hurley L.H., Anderson K.C., Munshi N.C.
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma.
Mol. Cancer Ther. 2:825-833(2003)

PubMed=15381930; DOI=10.1038/sj.bjc.6602160
Wang Z., Zhang Y., Ramsahoye B., Bowen D., Lim S.H.
Sp17 gene expression in myeloma cells is regulated by promoter methylation.
Br. J. Cancer 91:1597-1603(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A760
Anatomy/cell type resources BTO; BTO:0003930
Encyclopedic resources Wikidata; Q54750449
Polymorphism and mutation databases Cosmic; 720774
Cosmic; 760398
Cosmic; 2302413
Cosmic; 2367270
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16