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Cellosaurus U-178MG (CVCL_A758)

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Cell line name U-178MG
Synonyms U-178-MG; U-178 MG; U178-MG; U 178 MG; U178MG; MG 178; U-178; 178 MG; 178MG; 178 MG(5)
Accession CVCL_A758
Resource Identification Initiative To cite this cell line use: U-178MG (RRID:CVCL_A758)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 45 hours (PubMed=25984343).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Sequence variations
  • Mutation; HGNC; HGNC:5382; IDH1; None_reported; -; Zygosity=- (PubMed=19435942).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA); ClinVar=VCV000142259; Zygosity=Homozygous (PubMed=10560660; DepMap=ACH-000208).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Heterozygous (DepMap=ACH-000208).
HLA typing Source: PubMed=77569
Class I
HLA-AA*01,02
HLA-BB*07,12
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.94
Native American0
East Asian, North4.06
East Asian, South0
South Asian0
European, North69.5
European, South23.49
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): PubMed=22570425; PubMed=27582061

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133814,15
D3S135817
D5S81812,13
D7S8208,10 (PubMed=27582061)
10 (PubMed=22570425)
D8S117913,14
D13S31710,11 (PubMed=27582061)
11 (PubMed=22570425)
D16S53910,13
D18S5114,15
D19S43314,15
D21S1128,30
FGA22,26
Penta D7,12
Penta E7,12
TH017
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=4134536; DOI=10.1002/ijc.2910120215
Bengt Westermark;
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Int. J. Cancer 12:438-451(1973)

PubMed=4139097; DOI=10.1007/BF00295491
Joachim Mark, Jan Ponten, Bengt Westermark;
G-band analyses of an established cell line of a human malignant glioma.
Humangenetik 22:323-326(1974)

PubMed=4369403; DOI=10.1002/1097-0142(197408)34:2<274::AID-CNCR2820340209>3.0.CO;2-4
Torsten Wahlstrom, Ewert Linder, Eero Saksela, Bengt Westermark;
Tumor-specific membrane antigens in established cell lines from gliomas.
Cancer 34:274-279(1974)

DOI=10.1007/978-1-4757-1647-4_7
Jan Ponten;
Neoplastic human glia cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.175-206; Springer; New York; USA (1975)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x
Jons Ake Espmark, Lena Ahlqvist-Roth, Lena Sarne, Anita Persson;
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Tissue Antigens 11:279-286(1978)

PubMed=450131; DOI=10.1038/279797a0
Rufus S. Day 3rd, Chuck H.J. Ziolkowski;
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Nature 279:797-799(1979)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2454731
Monica Nister, Towia Aron Libermann, Christer Betsholtz, Monica Pettersson, Lena Claesson-Welsh, Carl-Henrik Heldin, Joseph Schlessinger, Bengt Westermark;
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
Cancer Res. 48:3910-3918(1988)

PubMed=1847665
Erik Bongcam-Rudloff, Monica Nister, Christer Betsholtz, Jia-Lun Wang, Goran Stenman, Kay Huebner, Carlo Maria Croce, Bengt Westermark;
Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
Cancer Res. 51:1553-1560(1991)

DOI=10.1016/B978-0-12-333530-2.50005-8
Monica Nister, Bengt Westermark;
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486
Nobuaki Ishii, Daniel Maier, Adrian Merlo, Mitsuhiro Tada, Yutaka Sawamura, Annie-Claire Diserens, Erwin G. Van Meir;
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=10560660; DOI=10.1097/00005072-199911000-00007
Esther E. Schmidt, Koichi Ichimura, Helena M. Goike, Ahmad Moshref, Lu Liu, Vincent Peter Collins;
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

PubMed=19435942; DOI=10.1215/15228517-2009-025; PMCID=PMC2743214
Koichi Ichimura, Danita M. Pearson, Sylvia Kocialkowski, L. Magnus Backlund, Raymond Chan, David T.W. Jones, Vincent Peter Collins;
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844
Pierre Bady, Annie-Claire Diserens, Vincent Castella, Stefanie Kalt, Karl Heinimann, Marie-France Hamou, Mauro Delorenzi, Monika E. Hegi;
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853
Marie Allen, Mia Bjerke, Hanna Edlund, Sven Nelander, Bengt Westermark;
Origin of the U87MG glioma cell line: good news and bad news.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A758
Cell_Model_Passport; SIDM01431
DepMap; ACH-000208
Biological sample resources BioSample; SAMN10988405
CRISP screens repositories BioGRID_ORCS_Cell_line; 692
Chemistry resources PharmacoDB; U178_1618_2019
Encyclopedic resources Wikidata; Q54973519
Experimental variables resources EFO; EFO_0022627
Polymorphism and mutation databases Cosmic; 849851
Cosmic; 849879
Cosmic; 1610740
Cosmic; 2516041
Progenetix; CVCL_A758
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number29