Cellosaurus cell line UKRV-Mel-12 (CVCL

Cellosaurus UKRV-Mel-12 (CVCL_A709)

Cross-references
Cell line name	UKRV-Mel-12
Accession	CVCL_A709
Resource Identification Initiative	To cite this cell line use: UKRV-Mel-12 (RRID:CVCL_A709)
Comments	Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072. Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17311103; PubMed=23348503). Mutation; HGNC; HGNC:11730; TERT; Simple; c.228_229CC>TT (-124/-125CC>TT); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	29Y
Category	Cancer cell line
Publications	PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595 Selma Ugurel, Ranjit K. Thirumaran, Sandra Bloethner, Andreas Gast, Antje Sucker, Jan Mueller-Berghaus, Werner Rittgen, Kari Hemminki, Jurgen C. Becker, Rajiv Kumar, Dirk Schadendorf; B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. PLoS ONE 2:e236.1-e236.13(2007) PubMed=23348503; DOI=10.1126/science.1230062 Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar; TERT promoter mutations in familial and sporadic melanoma. Science 339:959-961(2013)
Cell line databases/resources	cancercelllines; CVCL_A709
Encyclopedic resources	Wikidata; Q54990566
Polymorphism and mutation databases	Cosmic; 1846696 Cosmic; 2686509
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	18