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Cellosaurus A4H12 (CVCL_A6KJ)

[Text version]
Cell line name A4H12
Accession CVCL_A6KJ
Resource Identification Initiative To cite this cell line use: A4H12 (RRID:CVCL_A6KJ)
Comments Group: Hybridoma fusion partner cell line.
Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0013 (MOLT-4)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line

PubMed=1368811; DOI=10.1007/BF02525493
Kuroita T., Tachibana H., Ohashi H., Shirahata S., Murakami H.
Growth stimulating activity of heat shock protein 90 alpha to lymphoid cell lines in serum-free medium.
Cytotechnology 8:109-117(1992)

PubMed=1576323; DOI=10.3233/HAB-1992-3102
Kawahara H., Shirahata S., Tachibana H., Murakami H.
In vitro immunization of human lymphocytes with human lung cancer cell line A549.
Hum. Antibodies Hybridomas 3:8-13(1992)

Seki K., Kawahara H., Sato S., Tachibana H., Kido I., Hashimoto A., Hashizume S., Murakami H.
Reactivity of human monoclonal antibody BD9-D12 to cancer cells and tissues.
(In) Animal cell technology. Basic and applied aspects, Vol. 5; Kaminogawa S., Ametani A., Hachimura S. (eds.); pp.647-652; Springer; Dordrecht (1993)

Cell line databases/resources cancercelllines; CVCL_A6KJ
Encyclopedic resources Wikidata; Q107113322
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number7