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Cellosaurus WIL2 AGr9 clone 3-1 (CVCL_A6HT)

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Cell line name WIL2 AGr9 clone 3-1
Synonyms AGr9 clone 3-1; AGR9 cl 3 sc 1
Accession CVCL_A6HT
Resource Identification Initiative To cite this cell line use: WIL2 AGr9 clone 3-1 (RRID:CVCL_A6HT)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=4527800; DOI=10.1073/pnas.71.7.2679; PMCID=PMC388531
Julia E. Lever, George Nuki, Jarvis Edwin Seegmiller;
Expression of purine overproduction in a series of 8-azaguanine-resistant diploid human lymphoblast lines.
Proc. Natl. Acad. Sci. U.S.A. 71:2679-2683(1974)

PubMed=893394; DOI=10.1016/S0021-9258(17)40020-2
Michael Steven Hershfield, Jarvis Edwin Seegmiller;
Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity.
J. Biol. Chem. 252:6002-6010(1977)

Cross-references
Encyclopedic resources Wikidata; Q107117454
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number6