Cellosaurus cell line MONO-7 (CVCL

Cellosaurus MONO-7 (CVCL_A654)

Cross-references
Cell line name	MONO-7
Synonyms	Mono-7; Monosomy 7
Accession	CVCL_A654
Resource Identification Initiative	To cite this cell line use: MONO-7 (RRID:CVCL_A654)
Comments	Population: Japanese. Karyotypic information: Monosomy of chromosome 7 (PubMed=11843295). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Unspecified (PubMed=11843295).
Disease	Childhood acute myeloid leukemia (NCIt: C9160) Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	2Y
Category	Cancer cell line
Publications	PubMed=11843295; DOI=10.1007/BF02981983 Fujisaki H., Takai K., Akihisa S., Tokimasa S., Matsuda Y., Ohta H., Osugi Y., Kim J.Y., Hosoi G., Sako M., Hara J. Establishment of a monosomy 7 leukemia cell line, MONO-7, with a ras gene mutation. Int. J. Hematol. 75:72-77(2002) PubMed=23955599; DOI=10.1038/ng.2731 Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K.-i., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat. Genet. 45:1232-1237(2013)
Cell line databases/resources	cancercelllines; CVCL_A654
Encyclopedic resources	Wikidata; Q54906376
Polymorphism and mutation databases	Cosmic; 697691 Cosmic; 975277 Cosmic; 1281336 Cosmic; 2089646
Entry history
Entry creation	06-Jun-2012
Last entry update	05-Oct-2023
Version number	15