Cellosaurus cell line IPH-926 (CVCL

Cellosaurus IPH-926 (CVCL_A625)

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Cell line name

IPH-926

Synonyms

IPH926

Accession

CVCL_A625

Resource Identification Initiative

To cite this cell line use: IPH-926 (RRID:CVCL_A625)

Comments

Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Expresses high level of ABCB1 mRNA (PubMed=22118813).
Doubling time: ~2 weeks (PubMed=19191266); 200 hours (Note=In the first 1-2 weeks), 80-120 hours (Note=After 2 weeks) (DSMZ=ACC-827).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Heterozygous (PubMed=19191266).
Mutation; HGNC; HGNC:1748; CDH1; Simple; p.Val82fs*13 (c.240_241insGGTG); Zygosity=Heterozygous (PubMed=19191266).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (PubMed=22945757).

Disease

Invasive breast lobular carcinoma (NCIt: C7950)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

72Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-827; PubMed=22118813

Markers:

Amelogenin	X
CSF1PO	10,12
D2S1338	19,20
D3S1358	15
D5S818	11
D7S820	9,11
D8S1179	13,15
D13S317	11
D16S539	12
D18S51	12,22
D19S433	16
D21S11	30
FGA	19
Penta D	9
Penta E	11,12
TH01	6 (DSMZ=ACC-827) 7 (PubMed=22118813)
TPOX	8,10
vWA	15,16

Publications

PubMed=19191266; DOI=10.1002/path.2495
Matthias Christgen, Henriette Bruchhardt, Catarina Hadamitzky, Cornelia Rudolph, Doris Steinemann, Dorothea Gadzicki, Britta Hasemeier, Daniel Romermann, Tim Focken, Till Krech, Matthias Ballmaier ...Show all 14 authors... , Brigitte Schlegelberger, Hans-Heinrich Kreipe, Ulrich Lehmann; Show fewer authors
Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer.
J. Pathol. 217:620-632(2009)

PubMed=22118813; DOI=10.1016/j.canlet.2011.09.038
Till Krech, Elisa Scheuerer, Robert Geffers, Hans-Heinrich Kreipe, Ulrich Lehmann, Matthias Christgen;
ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells.
Cancer Lett. 315:153-160(2012)

PubMed=22945757; DOI=10.1038/labinvest.2012.126
Matthias Christgen, Monika Noskowicz, Charlotte Heil, Elisa Schipper, Henriette Christgen, Robert Geffers, Hans-Heinrich Kreipe, Ulrich Lehmann;
IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes.
Lab. Invest. 92:1635-1647(2012)

PubMed=24344720; DOI=10.1111/cas.12276; PMCID=PMC7654255
Matthias Christgen, Robert Geffers, Hans-Heinrich Kreipe, Ulrich Lehmann;
IPH-926 lobular breast cancer cells are triple-negative but their microarray profile uncovers a luminal subtype.
Cancer Sci. 104:1726-1730(2013)

PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436
Matthias Christgen, Patrick W.B. Derksen;
Lobular breast cancer: molecular basis, mouse and cellular models.
Breast Cancer Res. 17:16.1-16.9(2015)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-827

Cell line databases/resources

cancercelllines; CVCL_A625
DSMZCellDive; ACC-827

Encyclopedic resources

Wikidata; Q54897973

Gene expression databases

GEO; GSE28089

Polymorphism and mutation databases

Cosmic; 1179081

Entry history

Entry creation

06-Jun-2012

Last entry update

10-Apr-2025

Version number