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Cellosaurus IPH-926 (CVCL_A625)

[Text version]
Cell line name IPH-926
Synonyms IPH926
Accession CVCL_A625
Resource Identification Initiative To cite this cell line use: IPH-926 (RRID:CVCL_A625)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Expresses high level of ABCB1 mRNA (PubMed=22118813).
Doubling time: ~2 weeks (PubMed=19191266); 200 hours (Note=In the first 1-2 weeks), 80-120 hours (Note=After 2 weeks) (DSMZ=ACC-827).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene deletion; HGNC; 1748; CDH1; Zygosity=Heterozygous (PubMed=19191266).
  • Mutation; HGNC; 1748; CDH1; Simple; p.Val82fs*13 (c.240_241insGGTG); Zygosity=Heterozygous (PubMed=19191266).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (PubMed=22945757).
Disease Invasive breast lobular carcinoma (NCIt: C7950)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-827; PubMed=22118813

Markers:
AmelogeninX
CSF1PO10,12
D2S133819,20
D3S135815
D5S81811
D7S8209,11
D8S117913,15
D13S31711
D16S53912
D18S5112,22
D19S43316
D21S1130
FGA19
Penta D9
Penta E11,12
TH016 (DSMZ=ACC-827)
7 (PubMed=22118813)
TPOX8,10
vWA15,16

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Publications

PubMed=19191266; DOI=10.1002/path.2495
Christgen M., Bruchhardt H., Hadamitzky C., Rudolph C., Steinemann D., Gadzicki D., Hasemeier B., Romermann D., Focken T., Krech T., Ballmaier M., Schlegelberger B., Kreipe H.-H., Lehmann U.
Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer.
J. Pathol. 217:620-632(2009)

PubMed=22118813; DOI=10.1016/j.canlet.2011.09.038
Krech T., Scheuerer E., Geffers R., Kreipe H.-H., Lehmann U., Christgen M.
ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells.
Cancer Lett. 315:153-160(2012)

PubMed=22945757; DOI=10.1038/labinvest.2012.126
Christgen M., Noskowicz M., Heil C., Schipper E., Christgen H., Geffers R., Kreipe H.-H., Lehmann U.
IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes.
Lab. Invest. 92:1635-1647(2012)

PubMed=24344720; DOI=10.1111/cas.12276
Christgen M., Geffers R., Kreipe H.-H., Lehmann U.
IPH-926 lobular breast cancer cells are triple-negative but their microarray profile uncovers a luminal subtype.
Cancer Sci. 104:1726-1730(2013)

PubMed=25757734; DOI=10.1186/s13058-015-0517-z
Christgen M., Derksen P.W.B.
Lobular breast cancer: molecular basis, mouse and cellular models.
Breast Cancer Res. 17:16.1-16.9(2015)

Cross-references
Cell line collections (Providers) DSMZ; ACC-827
Cell line databases/resources cancercelllines; CVCL_A625
DSMZCellDive; ACC-827
Encyclopedic resources Wikidata; Q54897973
Gene expression databases GEO; GSE28089
Polymorphism and mutation databases Cosmic; 1179081
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number15