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Cellosaurus ILKM2 (CVCL_A621)

[Text version]
Cell line name ILKM2
Synonyms ILKM-2
Accession CVCL_A621
Resource Identification Initiative To cite this cell line use: ILKM2 (RRID:CVCL_A621)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Doubling time: 120 hours (PubMed=2783335).
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: B-cell; CL=CL_0000236.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E2UG (ILKM2 Lyn)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
Publications

PubMed=2783335; DOI=10.1084/jem.169.1.339; PMCID=PMC2189192
Shimizu S., Yoshioka R., Hirose Y., Sugai S., Tachibana J., Konda S.
Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines.
J. Exp. Med. 169:339-344(1989)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=11429052; DOI=10.1111/j.1349-7006.2001.tb01142.x; PMCID=PMC5926752
Hanamura I., Iida S., Akano Y., Hayami Y., Kato M., Miura K., Harada S., Banno S., Wakita A., Kiyoi H., Naoe T., Shimizu S., Sonta S.-i., Nitta M., Taniwaki M., Ueda R.
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Jpn. J. Cancer Res. 92:638-644(2001)

PubMed=12886255; DOI=10.1038/sj.leu.2403026
Hayami Y., Iida S., Nakazawa N., Hanamura I., Kato M., Komatsu H., Miura I., Dave B.J., Sanger W.G., Lim B., Taniwaki M., Ueda R.
Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
Leukemia 17:1650-1657(2003)

PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2; PMCID=PMC1618545
Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J.
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)

PubMed=17229644; DOI=10.3324/haematol.10300
Sanda T., Iida S., Kayukawa S., Ueda R.
Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid.
Haematologica 92:115-120(2007)

PubMed=20079716; DOI=10.1016/j.bbrc.2010.01.038
Iqbal M.S., Tsuyama N., Obata M., Ishikawa H.
A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells.
Biochem. Biophys. Res. Commun. 392:415-420(2010)

Cross-references
Cell line databases/resources CGH-DB; 9149-4
Encyclopedic resources Wikidata; Q54897484
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number19