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Cellosaurus AM-3 (CVCL_A5XS)

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Cell line name AM-3
Accession CVCL_A5XS
Resource Identification Initiative To cite this cell line use: AM-3 (RRID:CVCL_A5XS)
Comments Population: Japanese.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1582; CCND1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Met1_Ala159del).
Derived from site: In situ; Bone, jaw, mandible; UBERON=UBERON_0001684.
Cell type: Ameloblast; CL=CL_0000059.
Disease Follicular ameloblastoma (NCIt: C27397)
Ameloblastoma (ORDO: Orphanet_314419)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=23706918; DOI=10.1016/j.oooo.2013.03.005
Toshiro Kibe, Takao Fuchigami, Michiko Kishida, Mikio Iijima, Kiyohide Ishihata, Hiroshi Hijioka, Akihiko Miyawaki, Ichiro Semba, Norifumi Nakamura, Tohru Kiyono, Shosei Kishida;
A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 115:780-788(2013)

PubMed=32348439; DOI=10.1590/1678-7757-2019-0558; PMCID=PMC7185982
Takao Fuchigami, Hajime Suzuki, Takuya Yoshimura, Toshiro Kibe, Elissa Chairani, Tohru Kiyono, Michiko Kishida, Shosei Kishida, Norifumi Nakamura;
Ameloblastoma cell lines derived from different subtypes demonstrate distinct developmental patterns in a novel animal experimental model.
J. Appl. Oral Sci. 28:e20190558.1-e20190558.7(2020)

PubMed=36452176; DOI=10.1016/j.mbplus.2022.100125; PMCID=PMC9703037
Deniz Bakkalci, Amir Zaki Abdullah Zubir, Syed Ali Khurram, Judith Pape, Kristiina Heikinheimo, Stefano Fedele, Umber Cheema;
Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment.
Matrix Biol. Plus 16:100125.1-100125.13(2022)

Cross-references
Encyclopedic resources Wikidata; Q107113354
Entry history
Entry creation20-May-2021
Last entry update10-Apr-2025
Version number8