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Cellosaurus NCI-H460/TPT10 ABCG2 KO (CVCL_A5XR)

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Cell line name NCI-H460/TPT10 ABCG2 KO
Accession CVCL_A5XR
Resource Identification Initiative To cite this cell line use: NCI-H460/TPT10 ABCG2 KO (RRID:CVCL_A5XR)
Comments Population: Caucasian.
Characteristics: Compared to the parent cell line, no longer resistant to topotecan (PubMed=33425914).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:74; ABCG2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5XQ (NCI-H460/TPT10)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=33425914; DOI=10.3389/fcell.2020.607275; PMCID=PMC7786180
Zi-Ning Lei, Qiu-Xu Teng, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Kimberly W. Lu, Dong-Hua Yang, John N.D. Wurpel, Zhe-Sheng Chen;
Establishment and characterization of a topotecan resistant non-small cell lung cancer NCI-H460/TPT10 cell line.
Front. Cell Dev. Biol. 8:607275.1-607275.10(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5XR
Encyclopedic resources Wikidata; Q107116540
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7