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Cellosaurus U-2OSTR (CVCL_A5VC)

[Text version]
Cell line name U-2OSTR
Synonyms U-2OS(TR)
Accession CVCL_A5VC
Resource Identification Initiative To cite this cell line use: U-2OSTR (RRID:CVCL_A5VC)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=24866169; DOI=10.1158/2326-6066.CIR-13-0224
Shen J.K., Cote G.M., Choy E., Yang P., Harmon D., Schwab J.H., Nielsen G.P., Chebib I., Ferrone S., Wang X.-H., Wang Y.-Y., Mankin H.J., Hornicek F.J., Duan Z.-F.
Programmed cell death ligand 1 expression in osteosarcoma.
Cancer Immunol. Res. 2:690-698(2014)

PubMed=25236161; DOI=10.1186/1471-2407-14-681
Duan Z.-F., Zhang J.-M., Ye S.-N., Shen J.K., Choy E., Cote G.M., Harmon D., Mankin H.J., Hua Y.-Q., Zhang Y., Gray N.S., Hornicek F.J.
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Cross-references
Encyclopedic resources Wikidata; Q107117158
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5